At or on?
We use at to talk about public holidays and weekends, but when we talk about a particular special day or weekend, we use on.
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*Note that American English speakers usually say on the weekend.
In or on?
We use in with morning, afternoon, evening and night, but we use on when we talk about a specific morning, afternoon, etc., or when we describe the part of the day.
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At or in?
In the night usually refers to one particular night; at night refers to any night in general:
I was awake in the night, thinking about all the things that have happened.
‘It’s not safe to travel at night,’ the officer said.
At the end or in the end?
We use at the end (often with of) to talk about the point in time where something finishes. We use in the end to talk about things that happen after a long time or after a series of other events:
At the end of the film, everyone was crying.
Not:
In the end of the film…
I looked everywhere for the book but couldn’t find it, so in the end I bought a new copy.
At the beginning or in the beginning?
We use at the beginning (often with of) to talk about the point where something starts. We usually use in the beginning when we contrast two situations in time:
At the beginning of every lesson, the teacher told the children a little story.
In the beginning, nobody understood what was happening, but after she explained everything very carefully, things were much clearer.