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The Humane Society of the United States is a large nonprofit organization based in Washington, D.C. "Founded" (established; created) in 1954, its mission is to "celebrate" (enjoy and be happy about) animals and "confront" (fight against and stop) "cruelty" (mean, unfair, and harmful treatment). The organization and its supporters try to protect animals through "advocacy" (trying to change laws) and "campaigns" (efforts to raise awareness and change how people think about something).

The Humane Society provides animal "rescue" (the act of saving a person or animal from a dangerous situation) and emergency response. The organization has "sanctuaries" (safe and protected areas for animals) and "wildlife rehabilitation centers," where people try to help "wild" (not domesticated; not pets) animals that have been injured, so that they can live in "the wild" (nature) again.

The organization "investigates" (researches) reports of animal "abuse" (mistreatment; harm). For example, in 2012 it rescued "exotic" (unusual and from far away) animals from a "squalid" (dirty and in very poor condition) zoo. The organization often rescues dogs from a "puppy mill" (a place that "breeds" (makes an animal reproduce) valuable dogs to make money, but does not treat the animals well). In addition, the organization tries to improve how animals are "kept" (taken care of) on farms, making sure that animals have enough room to move around comfortably before they are killed for "consumption" (to be eaten by humans).

Many communities have local "humane societies" that "take in" (take care of) "abandoned" (left without a home) animals and help people adopt the animals as pets. These local humane societies are not part of the Humane Society of the United States, but they may receive training and education from the national organization.