Individuals with a homozygous CCR5 mutation are immune to HIV infection, while heterozygous CCR5 mutations lead to a slower disease course.
具有純合CCR5突變的人對HIV感染具有免疫力。雜合CCR5突變則會減緩疾病進程。
| Front | HIV Virus binds CD4 as well as a coreceptor, either CCR5 on macrophages (early infection) or CXCR4 on T cells (late infection). Homozygous ____ mutation = Result? Heterozygous ____ mutation = Result? |
|---|---|
| Back | Homozygous CCR5 mutation = immunity. Heterozygous CCR5 mutation = slower course. |
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