The flashcard describes ganciclovir, a guanosine analog that is phosphorylated to monophosphate by a CMV viral kinase and to triphosphate by cellular kinases, preferentially inhibiting viral DNA polymerase.
La flashcard décrit le ganciclovir, un analogue de guanosine qui est phosphorylé en monophosphate par une kinase virale du CMV et en triphosphate par des kinases cellulaires, inhibant préférentiellement la DNA polymérase virale.
| Front | Ganciclovir Mech: what metabolite, formed by what enzyme? this drug is a what analog? how do cellular enzymes act on it? what does it inhibit? |
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| Back | 5′-monophosphate formed by a CMV viral kinase. Guanosine analog. Triphosphate formed by cellular kinases. Preferentially inhibits viral DNA polymerase. |
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