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Hiv Therapy Nrtis Moa Competitively Inhibit Nucleotide Binding

Front HIV therapy
NRTIs

MOA:
Competitively inhibit nucleotide binding to
reverse transcriptase and terminate the DNA
chain (lack a 3′ OH group).

Zidovudine has 2 special uses
Back
ZDV can be used for general prophylaxis
and during pregnancy to decrease risk of fetal
transmission.

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