The flashcard asks about the mechanism of action of aminoglycosides: irreversible inhibition of protein synthesis by binding to the 30S subunit, which can also cause ototoxicity and nephrotoxicity. They require active transport, making them ineffective against anaerobes.
La flashcard interroge sur le mécanisme d'action des aminoglycosides : inhibition irréversible de la synthèse protéique en se liant à la sous-unité 30S, ce qui peut également provoquer des effets ototoxiques et néphrotoxiques. Ils nécessitent un transport actif, les rendant inefficaces contre les anaérobies.
| Front | MOA: reversible or irreversible? inhibition of what? through binding to? also can cause?2 What does it require? so inneffective against? |
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