This flashcard details Clostridium tetani, its tetanospasmin toxin which is an enzyme (protease) cleaving synaptobrevin, preventing GABA and glycine release from spinal cord inhibitory interneurons, causing tetanus (muscle spasms, opisthotonos, risus sardonicus).
Cette flashcard détaille le Clostridium tetani, sa toxine tétanospasmine qui est une enzyme (protéase) clivant la synaptobrévine, empêchant la libération de GABA et de glycine des interneurones inhibiteurs de la moelle épinière, provoquant le tétanos (spasmes musculaires, opisthotonos, risus sardonicus).
| Front | Bugs with exotoxins: Inhibit neurotransmitter release: Clostridium tetani toxin: 1 Mechanism: this toxin is an ENZYME that does what? Manifestation: 3 toxin prevents release of?2 from 1 cell type where? AB toxin or no? |
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| Back | Risus sardonicus or rictus grin is a highly characteristic, abnormal, sustained spasm of the facial muscles that appears to produce grinning. |
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