Flucytosine is activated in fungal cells by cytosine deaminase into 5-FU, which inhibits thymidylate synthase, preventing DNA synthesis.
Flucitozin se aktivira u gljivičnim ćelijama putem citazin deaminaze u 5-FU, koji inhibira timirilat sintazu, sprečavajući sintezu DNK.
| Front | How is flucytosine activated in fungal cells? What is it converted into? What enzyme does it inhibit? |
|---|---|
| Back | Activated by cytosine deaminase into 5-FU which inhibits thymidylate synthase preventing conversion of dUMP→dTMP |
Tags: antifungal, drugs
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