Amphotericin B binds to ergosterol, creating pores in the cell membrane that cause ion and water leakage.
Amfotericin B se vezuje za ergosterol i stvara pore u membrani ćelijskog zida, uzrokujući curenje jona i vode iz ćelije.
| Front | Amphotericin B → MOA |
|---|---|
| Back | Binds ergosterol and causes leakage of membrane via pores → Na+ | K+ leak out and H2O follows |
Tags: antifungal, drugs
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