Botulism symptoms like diplopia, dyspnea, dysphagia, and dysphonia result from C.botulinum neurotoxin, formed from germinating spores in canned food, which blocks acetylcholine release.
Botulizmde, C.botulinum'un nörotoksini, konserve yiyeceklerdeki sporların çimlenmesiyle oluşur ve asetilkolin salınımını engelleyerek çift görme, nefes alma, yutma ve konuşma güçlüğü gibi belirtilere yol açar.
| Front | Botulism What are Symptoms? What is the Pathogenesis? |
|---|---|
| Back | Diplopia (double vision) Dyspnea (difficulty breating) Dysphagia (difficulty swallowing) Dysphonia (difficulty talking) Anerobic environment in canned food contaminated by C.botulinum ↓ Spores germinate and organism grows ↓ C.botulinum neurotoxin remains intracellular ↓ Autolysis releases neurotoxin into food ↓ If food containing the pre-formed neurotoxin is not cooked well, the neurotoxin will exert its effects ↓ Toxin is not actively secreted by the bacteria and is readily destroyed by heating |
Tags: microbiology
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