This flashcard states that Cilastatin is given with Carbapenems to increase their half-life and prevent degradation by inhibiting renal dehydropeptidase I.
This flashcard states that Cilastatin is given with Carbapenems to increase their half-life and prevent degradation by inhibiting renal dehydropeptidase I.
| Front | What drug is given with Carbapenems to ↑ their half life and prevent degradation by the kidneys? |
|---|---|
| Back | Cilastatin inhibits renal dehydropeptidase I at PTC which ↓renal metabolism of imipenem, increasing its half-life |
Tags: antimicrobial, drugs
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