This flashcard lists Delavirdine, Efavirenz, and Nevirapine as NNRTIs and explains their mechanism of action of inhibiting reverse transcriptase directly.
This flashcard lists Delavirdine, Efavirenz, and Nevirapine as NNRTIs and explains their mechanism of action of inhibiting reverse transcriptase directly.
| Front | (3) NNRTIs → mechanism of action |
|---|---|
| Back | Delavirdine Efavirenz Nevirapine Inhibit enzyme (reverse transcriptase) on sites different from NRTIs → original genetic information from HIV is in form of RNA and enzyme is needed to convert ssRNA to dsDNA → two classes of reverse transcriptase inhibitors → Non-Nucleoside Reverse Transcriptase Inhibitors (nevirapine) bind enzyme directly to block catalytic site → Nucleoside Reverse Transcriptase Inhibitors (zidovudine) are incorporated into DNA strand to prevent elongation |
Tags: antiviral, drugs
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