Vancomycin inhibits peptidoglycan formation by binding to D-ala-D-ala, preventing cross-bridges and a functional bacterial cell wall; it is used for MRSA, C. difficile, and Gram-positive bacteria. Adverse effects include nephrotoxicity, ototoxicity, thrombophlebitis, red man syndrome, and DRESS.
Vankomicin inhibira stvaranje peptidoglikana vezivanjem za D-alanil-D-alanin, sprečavajući formiranje poprečnih veza i funkcionalnog bakterijskog zida. Koristi se za MRSA, C.difficile i Gram-pozitivne bakterije. Neželjeni efekti uključuju nefrotoksičnost, ototoksičnost, tromboflebitis, crveni man sindrom i DRESS.
| Front | Vancomycin → MOA → (3) uses |
|---|---|
| Back | Inhibits peptidoglycan formation by binding the D-alanine-D-alanine portion of cell wall precursors → prevents formation of cross-bridges and functioning bacterial cell wall MRSA C.difficile Gram (+) bugs Nephrotoxic Ototoxic Thrombophlebitis Red Man Syndrome DRESS |
Tags: antimicrobial, drugs
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