| Front | What is the pathogenesis behind cholera toxin? |
|---|---|
| Back | V. cholerae toxin ADP-ribosylates Gs-α subunit ↓ Gs-α subunit activates adenylyl cyclase ↓ Increased cAMP levels ↓ Overactivates Protein Kinase A (PKA) ↓ PKA phosphorylates CFTR chloride channel ↓ Increased Cl- excretion followed by H2O efflux ↓ Characteristic "rice-water" diarrhea |
Tags: microbiology
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