| Front | H.pylori Describe (3) main features How do you diagnose? Where does it mainly colonize and what is it pathogenesis? What does it cause? What is the treatment? |
|---|---|
| Back | Flagellated (motile) Triple Catalase (+) Oxidase (+) Urease (+) Diagnosis ↓ Urea breath test H.pylori Ab | Fecal Ag Pathogenesis → Colonizes mainly antrum of stomach → urease hydrolyzes urea to release NH3+ and CO2 → ammonia causes ↑pH and alkaline environment which helps organism survive in acidic mucosa as the urine also becomes alkaline Manifestations ↓ Weight loss (pain due to eating) Gastritis Peptic ulcers (especially duodenal) ↑ risk of the following conditions ↓ Peptic ulcer disease Gastric Adenocarcinoma MALT Lymphoma Treatment ↓ Triple therapy ↓ Amoxicillin (Metronidazole if penicillin allergy) Clarithromycin PPI (Omeprazole) ↓ "Antibiotics Cure Pylori" Bismuth-based quadruple therapy in macrolide resistance |
Tags: microbiology
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