This flashcard describes Chloroquine's mechanism of action as blocking the heme polymerase enzyme in Plasmodium, preventing heme detoxification, and notes its use against all Plasmodium species except P. falciparum.
This flashcard describes Chloroquine's mechanism of action as blocking the heme polymerase enzyme in Plasmodium, preventing heme detoxification, and notes its use against all Plasmodium species except P. falciparum.
| Front | Chloroquine → MOA → use |
|---|---|
| Back | Blocks heme polymerase enzyme hich parasite uses to convert toxic heme to nont oxic form → buildup of toxic heme in Anopheles mosquito kills parasite → all plasmodium species except P.falciparum |
Tags: antiparasitic, drugs
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