Isoniazid (INH) inhibits mycolic acid synthesis, crucial for the bacterial cell wall. KatG activates INH to its active form. Adverse effects include Cytochrome P450 inhibition, peripheral neuropathy, and B6 deficiency.
Isoniazid (INH) inhibira sintezu mikolne kiseline, što je ključno za zid bakterijske ćelije. KatG aktivira INH u aktivni izonijazid. Neželjeni efekti uključuju inhibiciju citohroma P450, perifernu neuropatiju i nedostatak B6.
| Front | What is the MOA of Isoniazid? What are the adverse effects? |
|---|---|
| Back | Inhibits mycolic acid synthesis KatG ↓ INH→ catalase peroxidase→Isoniazid Adverse effects ↓ CytP450 inhibition Peripheral neuropathy B6 deficiency "INH Injures Neurons and Hepatocytes" |
Tags: antimicrobial, drugs
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