Stellate granulomas in skin lesions indicate intracellular bacterial infections that stimulate a Th1 response and granuloma formation; persistent extracellular bacteria can also cause granulomas.
A "stellate granuloma" in a non-healing skin lesion biopsy suggests an intracellular bacterial infection, likely triggering a Th1 immune response with CMI cytokines leading to granuloma formation. Extracellular bacteria can also cause granulomas due to their persistence.
| Front | Pt with non-healing skin lesion gets lesion biopsy and the path lab reports back that the lesion has characteristics of a stellate granuloma Which is the causal agent? |
|---|---|
| Back | Intracellular bug Causation of granulomas is the fact that they live intracellularly ↓ Stimulation of the Th1 arm of the immune response ↓ Production of the CMI cytokines ↓ Formation of granulomas in infected tissues ↓ Extracellular bugs will also produce granulomas but this is due to the chronic persistence and indigestibility of the pathogen |
Tags: microbiology
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