C. perfringens's major degradative toxin is lecithinase (phospholipase C), which destroys cell membranes leading to necrosis, while S.pyogenes uses hyaluronidase to break down the extracellular matrix, facilitating spread.
C.perfringens'in ana yıkıcı toksini lesitinaz (fosfolipaz C)'dir, bu da hücre zarını tahrip ederek nekroza yol açar; S.pyogenes'in hyaluronidazı ise hücre dışı matrisi parçalayarak enfeksiyonun yayılmasına yardımcı olur.
| Front | C.perfringens vs. S.pyogenes Major degradative toxins |
|---|---|
| Back | C. perfringens Lecithinase (aka phospholipase C)Degrades lecithin in cell membrane → cell membrane destruction → hemolysis → RBC/WBC/Platelet destruction → cell death → necrosis vs. S.pyogenes Hyaluronidase Cleaves hyaluronic acid in subcutaneous tissue → acts as a spreading factor for cellulitis |
Tags: microbiology
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