Question

S.aureus produces a superantigen, Toxic Shock Syndrome Toxin (TSST-1), which activates a large population of T lymphocytes by cross-linking MHC II and T-cell receptorsThis results in a clinical triad of fever | shock | desquamating rash in what (2) settings?

Accepted Answer

Retained foreign body (nasal packing | tampon) or surgical wound infection → provide a rich nutrient source (blood) for bacteria → palmar | plantar desquamation is a hallmark feature of Staphylococcal Toxic Shock Syndrome (STSS) which occurs 2 weeks after onset → in acute setting, macular rash seen on palms, soles, and area surrounding infection

Front	S.aureus produces a superantigen, Toxic Shock Syndrome Toxin (TSST-1), which activates a large population of T lymphocytes by cross-linking MHC II and T-cell receptors This results in a clinical triad of fever \| shock \| desquamating rash in what (2) settings?
Back	Retained foreign body (nasal packing \| tampon) or surgical wound infection → provide a rich nutrient source (blood) for bacteria → palmar \| plantar desquamation is a hallmark feature of Staphylococcal Toxic Shock Syndrome (STSS) which occurs 2 weeks after onset → in acute setting, macular rash seen on palms, soles, and area surrounding infection

Shock Toxic Syndrome Rash Infection S.Aureus Produces Superantigen