Giardia trophozoites colonize the small intestine, causing inflammation and villous atrophy, attaching to epithelial cells via a sucking disk to absorb nutrients and induce inflammation.
Giardia-trofotsiitit kolonisoivat ohutsuolen, aiheuttaen suolen tulehdusta ja nukkamaista atrofiaa, ja ne tarttuvat epiteelisoluihin imulevyllään, sitoen ja imeemalla ravintoaineita.
| Front | What is the MOA of the parasite below? |
|---|---|
| Back | Giardia trophozoites (pear-shaped trophozoite) colonize small gut → small bowel inflammation and villous atrophy (↓ absorptive capability) → trophozoites have four pairs of flagella and two nuclei which attach to epithelial cells in duodenal and jejunal crypts through a sucking disk on their ventral surface → trophozoites absorb nutrients from the host and cause inflammation | malabsorption |
Tags: microbiology
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