TSST-1, a superantigen from S. aureus, causes shock by activating T-cells and releasing massive amounts of cytokines.
TSST-1, a superantigen toxin produced by Staphylococcus aureus, binds MHC II to TCR, causing polyclonal T-cell activation and massive cytokine release (IL-1, IL-2, IFN-γ, TNF-α), leading to shock.
| Front | Describe mechanism of TSST-1 |
|---|---|
| Back | TSST-1 is a superantigen toxin that allows the binding of MHC II with TCR ↓ Polyclonal T-cell activation with overwhelming IL-1 | IL-2 | IFN-γ | TNF-α release ↓ Shock |
Tags: microbiology
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