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Vaccine Virulence Factors Mechanism Treatment Gi Vi Fever

Front Salmonella

Main features 
Sources
Virulence Factors
Mechanism
Manifestations
Treatment
Vaccine
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Gram (-) rods
Oxidase (-) 
Lactose (-)
Flagellar organism which swims
H2S production

Sources: 
Poultry 
Uncooked meat
 ↓


Mechanism
 ↓
Invade GI tract via M cells of Peyer patches




Virulence Factors
 ↓ 
Endotoxin | Vi capsule

Manifestations:
Typhoid Fever → Fever | Rose spots on abdomen | Constipation | Abdominal pain | GI ulceration | Hemorrhage)



Treatment
Ceftriaxone | Fluoroquinolone 

Vaccine
 ↓
Oral vaccine 
(Live attenuated S.typhi)


IM vaccine contains Vi capsular polysaccharide

Tags: microbiology

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