Apedia

A-Level Biology OCR A

Dna Histones Tightly Coil Genes Explain Modification Affect

Histone modification affects gene expression by altering histone charge. Acetylation/phosphorylation reduces positive charge, loosening coils and allowing transcription, while methylation increases positive charge, tightening coils and inhibiting transcription.

Histone modification affects gene expression by altering histone charge. Acetylation/phosphorylation reduces positive charge, loosening coils and allowing transcription, while methylation increases positive charge, tightening coils and inhibiting transcription.

Front Explain how histone modification can affect gene expression.
Back Histone modification:
  • DNA wraps around histones bc DNA is negatively charged, histones are positively charged
  • Acetylation/phosphorylation reduces positive charge on histones and causes DNA to coil less tightly - certain genes can be transcribed
  • Methylation makes histones hydrophobic so they bind more tightly to each other, causing DNA to coil more tightly - certain genes transcription prevented

Learn with these flashcards. Click next, previous, or up to navigate to more flashcards for this subject.

Next card: Define operon group genes control regulatory mechanism expressed

Previous card: Chromatin cell genes heterochromatin explain remodelling division transcribed

Up to card list: A-Level Biology OCR A