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A-Level Biology OCR A

Dna Histones Tightly Coil Genes Explain Modification Affect

Front Explain how histone modification can affect gene expression.
Back Histone modification:
  • DNA wraps around histones bc DNA is negatively charged, histones are positively charged
  • Acetylation/phosphorylation reduces positive charge on histones and causes DNA to coil less tightly - certain genes can be transcribed
  • Methylation makes histones hydrophobic so they bind more tightly to each other, causing DNA to coil more tightly - certain genes transcription prevented

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