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Permanently Cofactor Attached Explain Zinc Ion Forms Important

Zinc ions in carbonic anhydrase are prosthetic groups (permanently attached, inorganic) rather than coenzymes or simply cofactors.

Zinc ions in carbonic anhydrase are prosthetic groups because they are permanently attached; they are inorganic, so not coenzymes, and the term prosthetic group is more specific than cofactor.

Front Explain why zinc ion that forms an important part of the structure of carbonic anhydrase is a prosthetic group, not a cofactor or coenzyme.
Back Not a cofactor:
  • It is permanently attached, stating that it is a cofactor is ambiguous, as cofactors include both permanently and not permanently attached components

Not a coenzyme:
  • It is inorganic, coenzymes are organic only

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