Neuromuscular junction (NMJ) events begin with an action potential (AP) at the motor neuron terminal, leading to calcium influx and ACh release. ACh binds to receptors on the muscle membrane, causing depolarization (end plate potentials) which triggers an AP. This AP propagates into the T-tubules, releasing calcium from the SR, and terminates when ACh is degraded by acetylcholinesterase.
1. AP in motor neuron arrives @ axons terminal 2. Ca enters terminal to trigger ACh release 3. ACh release into cleft 4. ACh binds to ACh receptors on muslce cell membrane 5. Binding of ACh to receptors opens Na Channels to gererate LP (end plate potentials) 6. end plate potentials open VG Na channels to increase Na influx 7. Massive Na entry triggers AP in muscle cell 8. AP is propogated into the cells through T tubes which triggers Ca release from SR 9. ACh is eventually degraded by acetylcholinesterase to terminate neural stimulation
| Front | Explain the events of NMJs |
|---|---|
| Back | 1. AP in motor neuron arrives @ axons terminal 2. Ca enters terminal to trigger ACh release 3. ACh release into cleft 4. ACh binds to ACh receptors on muslce cell membrane 5. Binding of ACh to receptors opens Na Channels to gererate LP (end plate potentials) 6. end plate potentials open VG Na channels to increase Na influx 7. Massive Na entry triggers AP in muscle cell 8. AP is propogated into the cells through T tubes which triggers Ca release from SR 9. ACh is eventually degraded by acetylcholinesterase to terminate neural stimulation |
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