During the plateau phase of the action potential, voltage-gated Ca2+ channels open, allowing Ca2+ entry that triggers calcium-induced calcium release from the SR. This released Ca2+ binds to troponin, initiating muscle contraction via the sliding filament mechanism.
1. During the plateau phase of AP, VG Ca channels open in the plasma membrane 2. Ca entry stimulates the opening of Ca channels in the SR known as <b>Ca-induced Ca release</b> <b>3.</b> SR releases Ca which binds to troponin to induce contraction of muscle <img src="paste-377d4fbf271a1b44f5782f107276307e7304124d.jpg">
| Front | How does the AP trigger contraction of the heart muscle by the sliding filament mechanism during depolarization? |
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| Back | 1. During the plateau phase of AP, VG Ca channels open in the plasma membrane 2. Ca entry stimulates the opening of Ca channels in the SR known as Ca-induced Ca release 3. SR releases Ca which binds to troponin to induce contraction of muscle |
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