Calcium plays a key role in long-term potentiation by triggering the influx of Ca and Na through NMDA receptors upon glutamate binding, leading to increased AMPA receptor expression, enhanced EPSPs, release of NO to boost presynaptic glutamate release, and synaptic remodeling.
1. After glutamate is released from the presynaptic neuron it binds to NMDA receptors which triggers influx of Ca and Na<div>2. Increased Ca triggers up expression of AMPA receptors in the membrane (post synaptic cell has more receptors to respond to glutamate)</div><div>3. Next time glutamate is released; both receptor types act together to trigger a bigger EPSP</div><div>4. Increased Ca also triggers release of NO which acts on presynaptic neuron to increase release of glutamate</div><div>5. Ca also triggers synaptic remodeling</div>
| Front | What is the role of Ca in long term potentiation? |
|---|---|
| Back | 1. After glutamate is released from the presynaptic neuron it binds to NMDA receptors which triggers influx of Ca and Na 2. Increased Ca triggers up expression of AMPA receptors in the membrane (post synaptic cell has more receptors to respond to glutamate) 3. Next time glutamate is released; both receptor types act together to trigger a bigger EPSP 4. Increased Ca also triggers release of NO which acts on presynaptic neuron to increase release of glutamate 5. Ca also triggers synaptic remodeling |
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