Initiation of translation involves mRNA entering the cytosol, the small ribosomal unit binding to the mRNA's leader sequence and moving to the start codon (AUG), the initiator tRNA pairing with the start codon, and the large ribosomal subunit joining to form a complete ribosome with the initiator tRNA in the P site.
1. mRNA is released into cytosol<div>2. Small ribosomal unit binds to leader sequence of bases as 'cap' end of mRNA</div><div>3. small unit slides along mRNA until it recognizes start codon of AUG</div><div>4. Initiator tRNA with anticodon of UAC & methionine attached at the amino acid binding end pairs w/ start codon</div><div>5. Large ribosomal subunit joins w/ the small subunit</div><div>6. Initiator tRNA occupies the P site and the A site is now ready to accept the next tRNA</div>
| Front | What are the steps of initiation (Translation) |
|---|---|
| Back | 1. mRNA is released into cytosol 2. Small ribosomal unit binds to leader sequence of bases as 'cap' end of mRNA 3. small unit slides along mRNA until it recognizes start codon of AUG 4. Initiator tRNA with anticodon of UAC & methionine attached at the amino acid binding end pairs w/ start codon 5. Large ribosomal subunit joins w/ the small subunit 6. Initiator tRNA occupies the P site and the A site is now ready to accept the next tRNA |
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