Major synaptic events include the arrival of an action potential at the axon terminal, opening voltage-gated calcium channels, calcium influx causing synaptic vesicle fusion and neurotransmitter (NT) release into the synaptic cleft, NT binding to postsynaptic receptors (ligand-gated channels), generating a local potential, and finally, if threshold is reached, triggering a new action potential in the postsynaptic neuron.
1. Action potential arrives at axon terminal <div>2. Arriving depolarization opens voltage-gated calcium channels</div><div>3. Calcium influxes into axon terminal which triggers fusion of synaptic vesicles containing NT w/ the cell membrane</div><div>4. NT released into synaptic cleft</div><div>5. NT diffuse across the synaptic cleft to bind to receptors on postsynaptic neuron</div><div>6. Receptors act as ligand gated channels which open to allow for influx of ions into the postsynaptic neuron & generates local potential</div><div>7. Spreading local potential to trigger zone of post synaptic neuron triggers new AP</div>
| Front | What are the major events at the synapse? |
|---|---|
| Back | 1. Action potential arrives at axon terminal 2. Arriving depolarization opens voltage-gated calcium channels 3. Calcium influxes into axon terminal which triggers fusion of synaptic vesicles containing NT w/ the cell membrane 4. NT released into synaptic cleft 5. NT diffuse across the synaptic cleft to bind to receptors on postsynaptic neuron 6. Receptors act as ligand gated channels which open to allow for influx of ions into the postsynaptic neuron & generates local potential 7. Spreading local potential to trigger zone of post synaptic neuron triggers new AP |
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