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Active Inhibitors Shape Site;  Explain Affect Rate Enzyme Controlled

Inhibitors slow enzyme reactions by competitively blocking the active site or non-competitively distorting it, both hindering enzyme-substrate complex formation.

Inhibitors reduce enzyme activity by either competitively binding to the active site or non-competitively binding elsewhere to distort the active site, both preventing enzyme-substrate complex formation.

Front Explain how inhibitors affect the rate of enzyme-controlled reactions. (6 marks)
Back Competitive 
Similarity of shape of inhibitor and substrate; 
Inhibitor can enter/bind with active site (of enzyme);

Non-competitive
Affect/bind to enzyme other than at active site; 
Distorts shape of active site;

Inhibitors
Prevent entry of/binding of substrate to active site; 
Therefore fewer/no enzyme-substrate complexes formed;

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