Question

Explain how inhibitors affect the rate of enzyme-controlled reactions. (6 marks)

Accepted Answer

Competitive

Similarity of shape of inhibitor and substrate;

Inhibitor can enter/bind with active site (of enzyme);

Non-competitive

Affect/bind to enzyme other than at active site;

Distorts shape of active site;

Inhibitors

Prevent entry of/binding of substrate to active site;

Therefore fewer/no enzyme-substrate complexes formed;

Front	Explain how inhibitors affect the rate of enzyme-controlled reactions. (6 marks)
Back	Competitive Similarity of shape of inhibitor and substrate; Inhibitor can enter/bind with active site (of enzyme); Non-competitive Affect/bind to enzyme other than at active site; Distorts shape of active site; Inhibitors Prevent entry of/binding of substrate to active site; Therefore fewer/no enzyme-substrate complexes formed;

Active Inhibitors Shape Site; Explain Affect Rate Enzyme Controlled