Enzyme specificity arises from their unique structure, forming a complementary active site for a substrate; non-competitive inhibitors distort this site, preventing substrate binding.
Enzymes are specific due to their unique primary structure and resulting tertiary structure, which creates a complementary active site for a specific substrate; non-competitive inhibitors bind elsewhere, distorting the active site so the substrate no longer fits.
| Front | Use your knowledge of protein structure to explain why enzymes are specific and may be affected by non-competitive inhibitors. (6 marks) |
|---|---|
| Back | each enzyme/protein has specific primary structure / amino acid sequence; folds in a particular way/ has particular tertiary structure; active site with unique structure; shape of active site complementary to/ will only fit that of substrate; maximum of three marks for inhibition, points 5 – 8 inhibitor fits at site on the enzyme other than active site; determined by shape; distorts active site; so substrate will no longer fit / form enzyme-substrate complex; |
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