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Active Site Structure Specific Fit Knowledge Protein Explain

Enzyme specificity arises from their unique structure, forming a complementary active site for a substrate; non-competitive inhibitors distort this site, preventing substrate binding.

Enzymes are specific due to their unique primary structure and resulting tertiary structure, which creates a complementary active site for a specific substrate; non-competitive inhibitors bind elsewhere, distorting the active site so the substrate no longer fits.

Front Use your knowledge of protein structure to explain why enzymes are specific and may be affected by non-competitive inhibitors. (6 marks)
Back each enzyme/protein has specific primary structure / amino acid sequence;

folds in a particular way/ has particular tertiary structure; 

active site with unique structure;

shape of active site complementary to/ will only fit that of substrate; maximum of three marks for inhibition, points 5 – 8 

inhibitor fits at site on the enzyme other than active site; 

determined by shape; 

distorts active site;

so substrate will no longer fit / form enzyme-substrate complex;

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