Non-competitive inhibitors bind to sites other than the active site, changing the enzyme's overall shape and rendering the active site unable to bind the substrate; increasing substrate concentration does not counteract this inhibition.
A non-competitive inhibitor binds to an allosteric site (not the active site), altering the enzyme's shape, including the active site, and preventing substrate binding. Increasing substrate concentration does not affect this inhibition.
| Front | What is non-competitive inhibition? |
|---|---|
| Back | molecule that attach themselves to the enzyme at a binding site which is not the active site, the inhibitor alters the shape of the enzyme and thus the active site thus a substrate can no longer bind and an enzyme substrate complex is not formed. Increasing the substrate concentration does not reduce the effect of the inhibitor. |
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