Competitive inhibitors resemble substrates and bind to the active site, reversible with high substrate concentration; non-competitive inhibitors bind elsewhere, causing irreversible active site distortion.
Competitive inhibitors resemble the substrate and bind to the active site, while non-competitive inhibitors bind elsewhere, causing irreversible distortion of the active site; competitive inhibition can be overcome by increasing substrate concentration, but non-competitive cannot.
| Front | State three differences between competitive and non-competitive inhibitors ( 3 marks) |
|---|---|
| Back | competitive inhibitors (CIs) structurally similar to substrate non-competitive inhibitors(NCIs) not similar CIs bind to active site, NCIs bind elsewhere on enzyme; effect of NCI is permanent/cannot be reversed by increasing substrate concentration whereas Cl effect is temporary/can be reversed by high substrate concentration; |
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