At the neuromuscular junction, an action potential triggers Ca2+ influx, causing acetylcholine release that binds to sarcolemmal receptors, opening Na+ channels and initiating depolarization along the sarcolemma and T tubules.
- action potential at motor neurone terminal - Ca2+ channels open - Ca2+ diffuse in - vesicle fuses with cell membrane - releases acetylcholine by exocytosis - acetylcholine diffuses across synaptic cleft - acetylcholine binds to Na+ channel receptors on sarcolemma - Na+ channels open - Na+ diffuses in - wave of depolarisation passes along sarcolemma and T tubules
| Front | What happens at the neuromuscular junction? |
|---|---|
| Back | - action potential at motor neurone terminal - Ca2+ channels open - Ca2+ diffuse in - vesicle fuses with cell membrane - releases acetylcholine by exocytosis - acetylcholine diffuses across synaptic cleft - acetylcholine binds to Na+ channel receptors on sarcolemma - Na+ channels open - Na+ diffuses in - wave of depolarisation passes along sarcolemma and T tubules |
Tags: nerves
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