A single amino acid substitution can have a greater effect if it alters the amino acid's charge or involves it in bonding (hydrogen, ionic, disulfide), significantly impacting the enzyme's tertiary structure.
- change in amino acid charge - amino acid involved in hydrogen/ionic/disulfide bond - larger effect on tertiary structure
| Front | Why would one amino acid substitution have a greater affect than another amino acid substitution? |
|---|---|
| Back | - change in amino acid charge - amino acid involved in hydrogen/ionic/disulfide bond - larger effect on tertiary structure |
Tags: exam, proteins
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