Glucagon raises blood glucose by binding to liver cell receptors, activating enzymes that break down glycogen into glucose (glycogenolysis) and synthesize glucose from other molecules (gluconeogenesis).
- decrease in blood glucose concentration detected by α cell receptors - α cells secrete glucagon - attaches to glucagon receptor on surface of target cells - receptor activates adenylate cyclase enzyme - adenylate cyclase converts ATP into cyclic AMP - cAMP acts as a second messenger and activates protein kinase - protein kinase converts glycogen into glucose by glycogenolysis - protein kinase converts amino acids and glycerol into glucose by gluconeogenesis - maintains larger concentration gradient of glucose for - more facilitated diffusion of glucose out of the cell - increase in blood glucose concentration
| Front | How does glucagon work? |
|---|---|
| Back | - decrease in blood glucose concentration detected by α cell receptors - α cells secrete glucagon - receptor activates adenylate cyclase enzyme - adenylate cyclase converts ATP into cyclic AMP - cAMP acts as a second messenger and activates protein kinase - protein kinase converts glycogen into glucose by glycogenolysis - protein kinase converts amino acids and glycerol into glucose by gluconeogenesis - maintains larger concentration gradient of glucose for - more facilitated diffusion of glucose out of the cell - increase in blood glucose concentration |
Tags: homeostasis
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