A receptor tyrosine kinase is a receptor protein in the plasma membrane, the cytoplasmic (intracellular) part of which can catalyze the transfer of a phosphate group from ATP to a tyrosine on another protein. These often respond to the binding of a signaling molecule by dimerizing and then phosphorylating a tyrosine on the cytoplasmic portion of the other receptor in the dimer. The phosphorylated tyrosines on the receptors then activate other signal transduction proteins within the cell.
Uma tirosina quinase receptora é uma proteína receptora na membrana plasmática, cuja parte citoplasmática (intracelular) pode catalisar a transferência de um grupo fosfato do ATP para uma tirosina em outra proteína. Estes frequentemente respondem à ligação de uma molécula sinalizadora dimerizando e, em seguida, fosforilando uma tirosina na porção citoplasmática do outro receptor no dímero. As tirosinas fosforiladas nos receptores ativam outras proteínas de transdução de sinal dentro da célula.
| Front | receptor tyrosine kinase |
|---|---|
| Back | A receptor protein in the plasma membrane, the cytoplasmic (intracellular) part of which can catalyze the transfer of a phosphate group from ATP to a tyrosine on another protein. [These] often respond to the binding of a signaling molecule by dimerizing and then phosphorylating a tyrosine on the cytoplasmic portion of the other receptor in the dimer. The phosphorylated tyrosines on the receptors then activate other signal transduction proteins within the cell. |
Tags: ch.11
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