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Affect Give Main Disadvantages Controlling Insect Pests Gene

Front
Give 2 main disadvantages for controlling insect pests
Back
Any 2 of below:
-Not sure how the gene will affect other tomato genes / characteristics / named characteristic
-Toxin might affect other organisms that feed on plant
-Genetic engineering unethical/unnatural
-Can't predict the effect of mutations
-Could mutate to form a human toxin

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