While the cause of primary pulmonary hypertension is unclear, familial cases linked to inactivating BMPR2 mutations lead to thickened blood vessel walls due to smooth muscle proliferation.
The etiology of primary pulmonary hypertension is unknown, but some familial forms are related to inactivating mutations of BMPR2, resulting in proliferation of vascular smooth muscle (i.e., thickening of vessel walls).
| Front | The etiology of primary pulmonary hypertension is unknown, but some familial forms are related to ___. This results in ___. |
|---|---|
| Back | inactivating mutations of BMPR2; proliferation of vascular smooth muscle (i.e., thickening of vessel walls) |
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