The signal recognition particle (SRP) binds to a signal sequence on a nascent polypeptide, halting translation until the SRP-ribosome complex docks at an ER receptor, where translation re-initiates and the polypeptide grows into the ER lumen via a transport channel before being vesicularized or embedded in the membrane.
Présence d'un signal -> recrutement du SRP, arrêt de la traduction jusqu'à ce que le complexe SRP-ribosome se fixe au récepteur sur la membrane du RE, ré-initiation de la traduction et la chaîne polypeptidique grandit dans la lumière du RE via un canal de transport, la protéine synthétisée est transportée via une vésicule/intégrée dans la membrane du RE, le SRP est clivé et recyclé.
| Front | conclusion to be made from comparison of methylation patterns in healthy and diseased twins |
|---|---|
| Back | methylation controls transcription and hence phenotypic expression of disease |
Tags: 7_2_transcription_gene_expression
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