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Methylation Conclusion Made Comparison Patterns Healthy Diseased Twins

The signal recognition particle (SRP) binds to a signal sequence on a nascent polypeptide, halting translation until the SRP-ribosome complex docks at an ER receptor, where translation re-initiates and the polypeptide grows into the ER lumen via a transport channel before being vesicularized or embedded in the membrane.

Présence d'un signal -> recrutement du SRP, arrêt de la traduction jusqu'à ce que le complexe SRP-ribosome se fixe au récepteur sur la membrane du RE, ré-initiation de la traduction et la chaîne polypeptidique grandit dans la lumière du RE via un canal de transport, la protéine synthétisée est transportée via une vésicule/intégrée dans la membrane du RE, le SRP est clivé et recyclé.

Front conclusion to be made from comparison of methylation patterns in healthy and diseased twins
Back methylation controls transcription and hence phenotypic expression of disease 

Tags: 7_2_transcription_gene_expression

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