Clonal selection theory posits that the adaptive immune system is based on individual antigen-specific lymphocytes that are self-tolerant. Upon antigen exposure, these lymphocytes expand and differentiate into effector cells that eliminate the pathogen and memory cells for lasting immunity.
La teoría de la selección clonal postula que el sistema inmunitario adaptativo se basa en linfocitos individuales específicos contra antígenos que son auto-tolerantes. Tras la exposición a un antígeno, estos linfocitos se expanden y diferencian en células efectoras que eliminan el patógeno y en células de memoria para una inmunidad duradera.
| Front | The central paradigm of adaptive immunity. It states that adaptive immune responses derive from individual antigen-specific lymphocytes that are self-tolerant. These specific lymphocytes proliferate in response to antigen and differentiate into antigen-specific effector cells that eliminate the eliciting pathogen, and into memory cells to sustain immunity. The theory was formulated by Macfarlane Burnet and in earlier forms by Niels Jerne and David Talmage |
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| Back | clonal selection theory |
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