Question

A disease characterized by a loss of tolerance to self antigens, caused by a breakdown of negative selection in the thymus. It is due to defects in the gene, AIRE, , which encodes a transcriptional regulatory protein that enables many self antigens to be expressed by thymic medullary epithelial cells. Also called autoimmune polyglandular syndrome type I

Accepted Answer

autoimmune polyendocrinopathy–candidiasis–ectodermal dystrophy APECED

Front	A disease characterized by a loss of tolerance to self antigens, caused by a breakdown of negative selection in the thymus. It is due to defects in the gene, AIRE, , which encodes a transcriptional regulatory protein that enables many self antigens to be expressed by thymic medullary epithelial cells. Also called autoimmune polyglandular syndrome type I
Back	autoimmune polyendocrinopathy–candidiasis–ectodermal dystrophy APECED

Autoimmune Disease Characterized Loss Tolerance Antigens Caused Breakdown