TAB1 and TAB2 are adaptor complexes that bind K63-linked polyubiquitin chains and, along with TAK1, direct TAK1 to signaling scaffolds to phosphorylate targets like IKKα.
An adaptor complex that binds K63 linked polyubiquitin chains. This complex along with TAK1, targeting TAK1 to signaling scaffolds where it phosphorylates substrates such as IKKα
| Front | An adaptor complex that binds K63 linked polyubiquitin chains. This complex along with TAK1, targeting TAK1 to signaling scaffolds where it phosphorylates substrates such as IKKα |
|---|---|
| Back | TAB1, TAB2 |
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