Unmethylated CpG dinucleotides, common in bacterial genomes but usually methylated in mammals, are recognized by TLR-9 in endosomes.
While mammalian genomes have heavily methylated the cytosine within CpG sequences, unmethylated CpG is more typically characteristic of bacterial genomes, and is recognized by TLR‑9 when encountered in the endosomal compartment
| Front | While mammalian genomes have heavily methylated the cytosine within CpG sequences, unmethylated CpG is more typically characteristic of bacterial genomes, and is recognized by TLR‑9 when encountered in the endosomal compartment |
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| Back | unmethylated CpG dinucleotides |
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