The hinge region is a flexible domain in immunoglobulins that connects the Fab arms to the Fc region, allowing the Fab arms to adjust their angles for optimal binding to epitopes at varying distances.
The flexible domain that joins the Fab arms to the Fc piece in an immunoglobulin. The flexibility of the hinge region in IgG and IgA molecules allows the Fab arms to adopt a wide range of angles, permitting binding to epitopes spaced variable distances apart
| Front | The flexible domain that joins the Fab arms to the Fc piece in an immunoglobulin. The flexibility of the hinge region in IgG and IgA molecules allows the Fab arms to adopt a wide range of angles, permitting binding to epitopes spaced variable distances apart |
|---|---|
| Back | hinge region |
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