Jun kinase is a protein kinase that phosphorylates the transcription factor c-Jun, enabling it to bind c-Fos to form the AP-1 transcription factor. Inositol 1,4,5-trisphosphate (IP3) is a soluble second messenger produced by cleavage of membrane inositol phospholipids by phospholipase C-γ, acting on ER membrane receptors to release stored Ca2+ into the cytosol.
La Jun quinasa es una proteína quinasa que fosforila el factor de transcripción c-Jun, permitiendo su unión a c-Fos para formar el factor de transcripción AP-1. El IP3 (inositol 1,4,5-trisP) es un segundo mensajero soluble producido por la escisión de fosfolípidos de inositol por la fosfolipasa C-γ, que actúa sobre receptores en la membrana del retículo endoplasmático para liberar Ca2+ almacenado.
| Front | A soluble second messenger produced by the cleavage of membrane inositol phospholipids by phospholipase C-γ. It acts on receptors in the endoplasmic reticulum membrane, resulting in the release of stored Ca, 2+, into the cytosol inositol 1,4,5-trisphosphate IP, 3A protein kinase that phosphorylates the transcription factor c-Jun, enabling it to bind to c-Fos to form the AP-1 transcription factor |
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| Back | Jun kinase |
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