The invariant chain (Ii, CD74) is a polypeptide that binds to newly synthesized MHC class II molecules in the ER, blocking it until degradation in the endosome allows antigenic peptide loading.
A polypeptide that binds in the peptide-binding cleft of newly synthesized MHC class II proteins in the endoplasmic reticulum and blocks other peptides from binding there. It is degraded in the endosome, allowing for loading of antigenic peptides there
| Front | A polypeptide that binds in the peptide-binding cleft of newly synthesized MHC class II proteins in the endoplasmic reticulum and blocks other peptides from binding there. It is degraded in the endosome, allowing for loading of antigenic peptides there |
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| Back | invariant chain Ii, CD74 |
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