Isotype switching is a process of somatic gene recombination in activated B cells that replaces one heavy-chain constant region with one of a different isotype, switching antibody production from IgM to IgG, IgA, or IgE without altering antigen specificity.
El cambio de isotipo es un proceso de recombinación génica somática en células B activadas que reemplaza una región constante de cadena pesada por otra de un isotipo diferente, cambiando la producción de anticuerpos de IgM a IgG, IgA o IgE sin alterar la especificidad antigénica.
| Front | A somatic gene recombination process in activated B cells that replaces one heavy-chain constant region with one of a different isotype, switching the isotype of antibodies from IgM to the production of IgG, IgA, or IgE. This affects the antibody effector functions but not their antigen specificity. Also known as class switching |
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| Back | isotype switching |
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