Cyclosporin A (CsA) is a potent noncytotoxic immunosuppressive drug that inhibits T-cell receptor signaling by binding cyclophilin, with the resulting complex inactivating calcineurin and blocking T-cell activation and function.
La ciclosporina A (CsA) es un potente fármaco inmunosupresor no citotóxico que inhibe la señalización del receptor de células T al unirse a la ciclofilina, y el complejo formado inactiva la calcineurina, bloqueando la activación y función de las células T.
| Front | A powerful noncytotoxic immunosuppressive drug that inhibits signaling from the T-cell receptor, preventing T-cell activation and effector function. It binds to cyclophilin, and the complex formed binds to and inactivates the phosphatase calcineurin |
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| Back | cyclosporin A CsA |
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